Main areas of research

Neuroimmunoendocrinology and cell signaling

Active investigators

Serge Rivest, Luc Vallières, Steve Lacroix, Nicolas Turin, Frédéric Calon, Thérèse DiPaolo, Charles Doillon, Christophe Garenc, Yohan Bossé, Marie Audette, Jean Gosselin, Jasna Kriz and Jean-Pierre Julien

For a better understanding of hormones and other messengers

In order to better understand cell signaling mechanisms and to discover new therapeutic targets, many investigators in this field study the role of hormones and other chemical and extracellular biochemical messengers in complex interactions with different physiological systems such as hormonal, nervous, immune and vascular systems, including angiogenesis.

Specifically, they wish to understand:

  1. The mechanism of action of cytokins and glucocorticoids in immune and endothelial brain, spinal cord and retinal cells;
  2. The neuroprotective effect of sex steroids;
  3. The implication of growth factors in the tissue distribution of angiogenesis;
  4. How brain tumour cells communicate with macrophages, lymphocytes and blood vessels;
  5. The influence of oxysterols on cell signaling in macrophages;
  6. The role of lipid mediators in the activation of the innate immune response;
  7. The influence of environmental factors on the progression of chronic inflammatory disease.

Strategies that use all platforms

Thanks to the availability of the genomics, proteomics, imagery, cytofluorometric and transgenic platforms as well as other joint services created by CREMOGH investigators, teams from the different fields of research can tackle and resolve complex research questions in collaboration with intra- and interarea members. A strategy that is often used by these investigators is gene identification as well as identification of the products involved in cell signaling by cutting-edge genomics, proteomics and imagery techniques. Identified signal pathways are then tested and validated in different in vitro and in vivo models, making the most of the transgenic approach.