Protein Crystallography

For a better understanding of the mechanisms of action

X-Ray protein crystallography makes it possible to study the three-dimensional physical structure of proteins and thus better understand their mechanisms of action and links with other molecules that are present in cells or administered as drugs.

Identifying molecular interaction sites

Crystallography of the enzymes responsible for steroid formation has helped the CREMOGH to identify the first enzyme structure responsible for steroid formation in humans,namely the one responsible for estradiol formation, a hormone essential to reproductive functions and the basis of fertility. Since the understanding of cell biology calls for detailed knowledge of the interactions between the different proteins and other parts of the cell, the crystallography platform is a major asset in the identification of molecular interaction sites that can be used for the action of specific inhibitors or activators in the efficient fight against disease.

The very high level of precision obtained also makes it possible to reproduce the protein on a computer and plan new molecules to be made by chemists. These molecules will be able to interact more efficiently with the enzyme and block its action more effectively while reducing side effects.